The reason for the MX-500 universal remotes is the one remote can control everything we want: TV, Apple TV, Blu-ray/DVD player, DVR+, receiver, digital input switcher, and X-10 controller. No remote clutter.
Plus my wife and I each have one at our seating positions, thus no "pass the remote" nonsense.
They work fine with everything but the Apple TV. Even then: They work acceptably with that, except with the Channels app.
Besides: It's not just the IR remotes. We really don't like much of anything about the way Channels works on Apple TV, as compared to the way it works on Fire TV and Android TV. To the point that, if I had another HDMI input, I'd probably hook the Fire TV back up just for Channels.