I have 6 TB free on a 10 TB drive, so that's not it...
Just checked, and yes it is. While Channels DVR on my AppleTV wasn't showing any guide data for Plex TV, I launched the Channels (for iPad) app on my M1 Mac, and my Plex Channel Collection was displaying guide data there. So I went back to the AppleTV and force-quit and relaunched Channels, but still didn't see guide data for Plex. So then finally I deleted the beta app entirely from AppleTV and re-installed it fresh from TestFlight. And now, finally, for the first time in a day or two, I do see guide data for Plex! I'll keep an eye on it moving forward and see if this fix sticks. Not sure why it would stop displaying like that, guide data from just one XMLTV source, on just one client, but sharing this information in the hopes it might help someone else out there navigating these same waters.
Thanks for the suggestions!