I am just using Adguard Home set to mostly default setting, which just uses thier own DNS block list, same one used if u just use the free DNS service from them. but since u run the DNS server locally, u have full control over it and can add remove lists etc. I have only enabled the secondary List for NoCoin.
It uses Quad9 Unsecured DND over HTTPS as its upsream DNS by default, but u can change it to whatever you want. I assume that is default, as the Adguard Home software it self you set to block what u want. I changed it to the Quad9 Secured w/ ECS support It include blocklist, DNSSEC validation, and other security features.
(there is no need to have Adguard DNS as the upstream DNS service, since, you are running locally the same thing, double filtering using the same list/service like that does nothing)
I still have to keep uBlock Origin installed in my browsers though, as that catches things that, so far, any DNS based ad block I have tried does not, like YT ads and on certain...torrent sites. to bad uBlock doesn't have a service like AdGuard Home or Pi-Hole.