Its important though to get a baseline signal level from the start and then see what you have to work with. The only potential negative thing about coax runs are attenuation (assuming you dont have twist on radio shack f connectors or breaks in the cable etc). You would think that you would always want the shortest rg6 run possible under all circumstances. But depending on your signal level it probably doesn't matter at all. 100ft of rg6 is going to lose about 2.5dB on VHF and 5dB on UHF. If you only have 20-30 feet of cable then your loss is minuscule.
I have my antenna feeding a 4 way splitter from a 30ft rg6 run. The 4-way looses 7dB and i still have a 9db attenuator added in front of the splitter. (My towers are 12miles from me).
My recommendation to those folks that think they need an amp...
Tune your antenna to get the best average signal across all channels then get your signal level right off the antenna to see what you are working with. Then add in your splitters etc and see what you have after that. Pre amps/signal amps etc may not be necessary, they are a solution to a problem. Make sure you have a problem to solve before implementing a solution.
How do you get your signal level? A signal meter would be nice but you can use your HDHR. Get the ios app signal gh. Then tune every tuner you have to a different station. Get the best average signal and then add your splitters etc and see where you are. If you do need an amp, add it as close to the antenna as possible. If the signal says 100% on every station (like mine), add cable attenuators until you get it just below 100%. HDHR's dont like to be overdriven...
But bottom line is cable, splitters, and even long cable runs are not bad as long as you have the headroom to work with...