I have an HDHomeRun PRIME (CableCard with three tuners).
I have found that using the Channels App for watching cable on a single TV will disrupt a MythTV recording. The MythTV works flawlessly if the Channels App is not used.
I tried evaluating Channels DVR as a replacement for MythTV (I was willing to pay the subscription fee) and found it lacking in specifying and managing record schedules.
Since I have three tuners, there should be no reason to why MythTV and Channels should not be able to coexist when they are each streaming a single program.
I have switched from using the Channels App to using the MythTV plugin with Kodi. Kodi runs native on Android based players and TVs. It also work extremely well on the Raspberry Pi 3 B+ using the LibreELEC distribution.