I amped it after the first split, because otherwise it was a little too strong for the modem. (Also, my modem and rack holding the Primes were on different sides of the office.)
I had to spend a weekend playing with the setup, moving the splits and amp to different locations in the chain in order to find what worked best. I am not a network engineer by any stretch, so I just had past experience and trial & error to guide my setup.
(Of course, now that I'm transitioning from cable to OTA, all of that work was for naught, but oh well ...)

I'd also rather them over a single hop of ethernet to my server, vs the Moca hop.
Then again, maybe you don't own the property and you don't have that luxury.