I have encountered this with multiple separate Fire TV sticks and Chromecast with Google TV devices using remote access, from two separate locations.
While watching live TV, playback will suddenly stop and go back to the TV Guide. In the log, I see these lines showing up quite a bit:
2022/01/21 10:09:13.197245 http: TLS handshake error from (remote IP of my client):59602: EOF
2022/01/21 10:10:05.319230 http: TLS handshake error from (remote IP of my client): read tcp 10.36.10.38:8089->(remote IP of my client):59606: read: connection reset by peer
This doesn't seem to happen if watching while on a local network with the DVR server, though I use Apple TV and xTeve/Plex with no problems.
It looks like this is happening with version 4.1.0 and 4.1.1 of the app on Chromecast, and 4.1.0 on Fire TV Stick.
Server version is 2022.01.15.1918. These problems +seem+ to have started after my Channels DVR server lost power, but that could be a coincidence. FWIW, I'm running Channels DVR in Docker on Unraid.